The Best Depression Medication

I am glad you stumbled on this article. If you have depression or you don’t, it is important to know the best depression medication. We could all benefit from this information by spreading awareness on the top depression treatments.

In this article, I will give you the run down of each medication. No I am not talking about prescribed medication or antidepressants. If you are looking for that, then you must see a doctor as they can only prescribe you that medication since those drugs can be classified as very powerful or dangerous.

I will be talking about over-the-counter drugs (OTC) that are in the form of natural supplements/vitamins. You have easy accessibility to these natural medications because they are extremely safe and beneficial. I will recommend the 5 best depression medications. These are truly the 5 best natural supplements you can take to help beat your depression. 

In fact, I do take these and have been for a while now. They come with very limited side effects if not any and prove to be extremely beneficial. In my personal experience with depression, they can be considered as effective as antidepressants.

So here are the top depression treatments in the form of natural medication where you can easily purchase online for the best available prices (links are in the title). I list the 5 best ones below.

I honestly recommend all of them. I take all of these specific ones and they are relatively inexpensive and work great together. If you are looking for one main depression supplement as your safe haven, then I would recommend 5-HTP. I started taking that supplement first out of the others and found it worked great.

5 Best Depression Medications:

  1. 5-HTP 
    • This natural supplement/vitamin works by increasing the level of serotonin (happy chemical) in your brain. I take my 5-HTP three times daily, one during breakfast, lunch, and dinner. I noticed also that the side effects are very limited. In fact, I did not have any. The time it took to start working was around one week. These are huge comparisons when talking about prescribed medication or antidepressants. With those, you may not find the right fit for a while, leaving you with nasty side effects for weeks or months. 
    • I think 5-HTP works for everyone. It has plenty of beneficial reviews and my only regret was that I wish I had jumped on it earlier. 5-HTP is extremely safe to take as it is a natural supplement. It is extremely difficult to overdose on it. In fact, taking too much will work the same as taking the right amount, so there is no point of taking extra. Follow the dosage guidelines. I would recommend 200-500 mg a day.
    • You can also read my full review on 5-HTP.
    • Rated 4.5 starts on Amazon.
  2. GABA
    • I take this for my depression and anxiety. I notice that depression and anxiety go hand in hand very often. Sometimes I find that when my depression is relieved, my anxiety will kick in or vice versa. I then researched a natural supplement that helps with anxiety. I came across GABA and saw plenty of great reviews so I gave it a shot. It worked great.
    • GABA is a natural vitamin that helps to calm the central nervous system, thereby giving you a calm, relaxed effect. This definitely helps with anxiety as it will calm your heart rate and put you in a soothing state. It also helps with chronic pain and epilepsy. Personally, I think this is the best supplement for anxiety and again wish I had jumped on it earlier. 
    • GABA is also extremely safe to take much like 5-HTP. It comes with very little side effects. I did not notice any actually. Again, like 5-HTP, it is pointless to take too much as your central nervous system will calm to the most effective state. Taking too much or the right amount will have the same effect.
    • I find by taking GABA, I am in a very relaxed mood. My worries, tension, and anxiety seem to disappear, allowing me to be more social and get things done during the day.
    • You can read my full review on GABA.
    • Rated 4.5 starts on Amazon.
  3. Turmeric
    • This is an all-around supplement I take. I take turmeric for my physical and mental health. There are numerous benefits associated with consuming turmeric supplements. These include the prevention of heart disease, depression, anxiety, Alzheimer’s, arthritis, brain disease, cancer, and delayed aging, increasing your life span. Essentially, turmeric is a very strong antioxidant and anti-inflammatory. Oxidation and inflammation are huge factors of disease development, both mentally and physically.
    • I take my turmeric supplement everyday and have actually got my mom and dad to do the same because of the benefits. We all noticed great improvements. My mom has bad arthritis and has had difficulty finding treatment for it. I recommended turmeric and she loves it. 
    • Nonetheless, this supplement will help you with your depression if that is what you are looking for. It is more of an all-around supplement kind of like a natural athlete, good at all sports. I will likely never stop taking this. It is extremely safe and you may not know, but turmeric is the natural ingredient found in curry and many Asian foods. However, it is difficult to consume the level of turmeric you need through foods, which is why I consume my turmeric supplements.
    • You can read my full review on turmeric.
    • Rated 4.5 stars with over 8000 customer reviews on Amazon.
  4. Omega-3 Fatty Acids
    • Omega-3s are considered fatty acids, meaning the body cannot make them directly, which is why we have to consume them through our diet or by supplementation. Common foods that contain a good level of Omega-3s are fish groups such as salmon, sardines, or mackerel. I take my Omega-3 in the natural supplement form. I actually do eat a lot of fish, but I take my Omega-3 supplements everyday to make sure I am getting the plentiful amount I need.
    • Much like turmeric, Omega-3s have many benefits associated with us both mentally and physically. You cannot go wrong with taking Omega-3s. Benefits include preventing heart disease and cardiovascular issues, treating arthritis by loosening stiffness and joint pain, reduction of depression symptoms, and protection against dementia and Alzheimer’s. 
    • I take my Omega-3 daily and find it works tremendously. Omega-3 is extremely safe and you would have to consume A LOT of it to experience side effects. Again, I won’t stop taking this supplement until the day I die. So many benefits. Everyone should take this.
    • You can read my full review on Omega-3.
    • Rated 4.5 stars and over 1000 reviews on Amazon.
  5. Essential Vitamins
    • Lastly, consume your vitamins everyone. A,B,C,D are all important for the many different reasons. You can of course attain your vitamin levels through food groups or natural processes such as sunlight, but again to ensure myself that I am getting the right levels, I take supplements. I currently take Vitamin B. For depression, I would definitely recommend this vitamin as your top essential vitamin out of the others (A,C,D). Vitamin B deficiency can be linked to mental conditions such as depression.
    • I currently consume Vitamin B supplements and try to attain my other vitamins through food groups such as leafy greens, whole grains, dairy, and meat.
    • Nonetheless, all vitamins are important for different reasons. However, if I had to stress one for your mental health, I would recommend Vitamin B.
    • Benefits of Vitamin B include increase energy levels, brain power, reduction of depression symptoms, and prevention of heart disease.
    • Rated 4.5 stars on Amazon.


There you go. Those are the top depression treatments and the best depression medication that is natural. Again, I recommend all of them as I do take all of them. However, my top recommendation solely for depression is 5-HTP. The links are in the titles that will take you directly to Amazon with the most efficient price available and to the one I specifically take.

If you are unsure about dosage and want to follow along with me, then I encourage you to get the products I have listed here and follow along with my dosage.

My Dosages:

  • 5-HTP (3 capsules per day)
  • GABA (1-2 capsule per day)
  • Omega-3 (1-2 capsule per day)
  • Turmeric (1 capsule per day)
  • Vitamins (B) (1 capsule per day)

Before you go, I would like to also encourage you to read my article on depression and exercise, and depression and diet. This is also very valuable information you could benefit from.

I hope this information has helped and if you have any questions or concerns, please leave a comment below.

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  1. A great article about non pharmaceutical treatments for depression.5 HTP and GABA I have not heard of before and I will check them out. Tumeric is a spice I use a lot of in cooking and I really thought that would be sufficient but you suggest it is not. I did know about omega 3’s and vitamin B and the benefits you can derive from them to fight depression. I wonder what is the underlying cause of depression.. If it is work or a relationship or financial pressure then perhaps no amount of medication will help. If it is none of these and really can’t be explained then your suggestions will surely be very helpful to a lot of people as it seems to be a big problem in modern society.

    • Hi Judy, thank you for reaching out. Turmeric is very healthy either way. If you use it in your cooking, then keep using it. Just to get All and the maximum benefits associated with turmeric, then supplementation is needed. This is because the ingredient you want to consume from turmeric is curcumin. The level of curcumin in turmeric is actually quite low. So when we make supplements, we take turmeric extracts that are high in curcumin to develop these supplements that then contain a very high level of curcumin.

      Either way, if you are using it in your cooking, it is definitely good for you. If you use turmeric often in many dishes, then this will add up and is definitely considered healthy. However, if you are experiencing any of the diseases turmeric has benefits for (depression, Alzheimer’s, arthritis, cancer, heart disease, brain disease etc.) Then I would recommend getting turmeric supplements. Nonetheless, you can’t go wrong with consuming supplements and using turmeric in your foods.

      Depression is a huge problem in our society today. There is not a set reason or underlying cause of depression. Anything can play a role such as brain chemistry, biology, genetics, environment, stress, hormones etc.) The problem is that there is a stigma revolving around these mental illnesses such as depression and that way too many people jump to pharmaceutical drugs that do more harm than good. That is why I like to stress natural remedies such as these medications/vitamins as well as exercise and healthy eating.

  2. Thanks for your recommendations of The Best Depression Medications that are non-prescription. Trying 5-HTP first is a good way to go. If it works, maybe the others would not be needed on a regular basis. However, as you mentioned, there are other health benefits in the supplements.

    • I agree with you Sandra. 5-HTP is the first natural supplement to get if you are depressed. Then from there, you can start focusing on other ones that have different effects such as GABA or turmeric. All these supplements I mentioned will help you with your mental health situation but 5-HTP is the top recommended product to go with first. I do take all these supplements listed but 5-HTP was the first one I went on and found that it worked great!

      Yes, in short, if 5-HTP works, maybe the others ones won’t be needed for some people. But again, they all have different characteristics and benefits. GABA helps with depression and anxiety. Turmeric and Omega-3 have numerous physical benefits as well as helping with depression. I like taking all of mine and have noticed great benefits all around physically and mentally.

  3. I feel really depressed these days I think I will get GABA since it is also used for bodybuilding.So I will have one more reason to go to a gym which I haven’t gone for years. I also really liked that it is natural.

    • Glad to hear. GABA is a great natural supplement for numerous mental and physical health reasons.

  4. Thanks for your recommendations on non-prescribed medications. I like the idea of taking natural supplements for this, as I have always been a big user of supplements for bodybuilding and gym training. I have used the Omega 3 in the past as it is good for the heart. I have recently tried doctor prescribed drugs, but they actually made me feel worse. I will definitely give the 5-HTP a try.

    • Thank you for reaching out Greg. Good to hear you have used Omega-3 in the past, but I would definitely continue to use it. It has many physical and mental benefits. Yes, prescribed drugs contain many side effects that make patients feel a lot worse before they can start to feel better. This is definitely the case for antidepressants. I would strongly recommend 5-HTP. It truly is a great natural supplement for depression.

  5. Great job!! It’s really worth reading your article. I liked your recommendations as these are natural and have limited side effects. It’s very hard being a patient of depression because sometimes it gets worst. I am also suffering from this illness and indeed will give a try to 5-HTP as it has a beneficial reviews and is extremely safe.

    • Thank you for reaching out Sarah. I like to stress natural remedies such as supplements because they do work. I am a depression patient also and find 5-HTP works great. I would strongly recommend it.

  6. Yes, Rob, depression is becoming a worldwide epidemic! The worst part is that medical science doesn’t offer any straight answers. I am a firm believer in natural medicine; totally against chemicals and altered nutrients. Have you considered that emotional states can also be the result of how we view life, our thoughts, our self-expectations? I believe that, together with the right vitamins and natural supplements, being honest with ourselves by acknowledging our thoughts and choosing the correct ones, we can have emotional balance. Stay happy 🙂

    • Completely agree. Depression is HUGE. I am for natural remedies such as exercise, supplementation, dieting, counseling etc. However, I do believe that there are circumstances where patients of depression feel the need that the only way to become better is by chemical alteration in the brain via antidepressants. However, I do think every depression patient should give natural remedies a try truly and fully before deciding this.

      Emotional states do play a large role of how we view life, thoughts, etc. The emotional state of depression makes people who are suffering develop negative thoughts and impulses, thereby making them feel hopeless and unwanted. That is the state of depression and what it does. It is complete darkness that takes over our mental states and views on life and thoughts. It truly isn’t us that are thinking these things. The depression takes over which is difficult to overcome. But I do agree that with the right natural treatment, it is completely possible to get out of the darkness.

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